Regarding the hypervariable regions (HVR), the HVR-1 showed the highest values for all parameters; the nHap and the number of synonymous substitutions per synonymous site (Ks) in this region were marginally significant, both being higher in non-responders.
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Baseline prediction of combination therapy outcome in hepatitis C virus 1b infected patients by discriminant analysis using viral and host factors.
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Some of the host factors that have previously been associated with treatment failure, such as male gender, advanced age, advanced liver fibrosis stage and cirrhosis [6] , [7] , [13] did not reach statistical significance in our study probably due to a limited sample size, especially regarding the liver biopsy, which was not performed in 37.2% of patients.