highly significantp < 2.2e-16
These differences, while modest in strength, were highly significant (p < 2.2e-16).
These differences, while modest in strength, were highly significant (p < 2.2e-16).
Also, there is a slight trend that the further away on the evolutionary timescale compared to human, the lower the mean IPC score for the i-i pairs.
There is less of a clear trend visible at the domain level [Additional file 7 ] compared to the functional enrichment analysis; however, the results are broadly compatible with the general trends we observed: enrichment of MHC-associated domains, protein kinase domains, ion channels and cell adhesion-related domains such as collagen and cadherin.