Barely Significant
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Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure.

PLoS One · 2010 · PMC2997078 · PMID 21151937

Europe PMCDOI
1
hedged sentence
0.0580
closest p · 1.2× alpha
0.0580
boldest claim

The sentences

showed a trendp = 0.058so close (0.05 < p ≤ 0.1)
1XMETH significantly reduced density of TH fibers in SNpr (Two-way ANOVA, treatment p<0.001, F (2,48) = 98.444; p<0.001, post hoc Newman-Keuls test; Fig 5A, B ) in both Nurr1 +/+ (n = 10) and +/− (n = 10) mice; Nurr1 +/− mice showed a trend towards greater decrease in THir in SNpr (Two-way ANOVA, p = 0.058, post hoc Newman-Keuls test). 2XMETH caused a further reduction in TH fiber density in SNpr in both Nurr1 +/+ (n = 8) and +/− (n = 7) animals (Two-way ANOVA, p<0.001, post hoc Newman-Keuls test).

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