Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.

Cell Death Dis · 2010 · PMC2998343 · PMID 21152247

Europe PMC DOI

hedged sentences

0.0720

closest p · 1.4× alpha

0.0720

boldest claim

The sentences

did not reach statistical significanceP =0.072so close (0.05 < p ≤ 0.1)

Expression of 14-3-3 ɛ and 14-3-3 σ trended downward but did not reach statistical significance ( P =0.072 for 14-3-3 ɛ ; P =0.088 for 14-3-3 σ ). 14-3-3 ɛ , - γ , and - θ reduce α -syn inclusion formation Because previous studies have revealed that α -syn and 14-3-3s are colocalized in Lewy bodies, we asked whether increased 14-3-3 expression could affect α -syn aggregation.

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a nonsignificant trendno p-value reported

The 14-3-3 η cells showed a nonsignificant trend toward increased toxicity in the presence of rotenone compared to control cells.

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