The results were moderately significant when compared with simulations under two demographic scenarios inferred from a previous modeling study ( Voight et al. 2005 ) and to the distribution of Tajima's D over a set of 50 randomly chosen loci sequenced in the same individuals ( Voight et al. 2005 ) ( P ≤ 0.043 and P = 0.04, respectively, using one-tailed tests of significance).
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Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance.
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