T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis.

Among the other variables tested individually in the Cox regression, we found that: (i) the whole brain T1 hypointense lesion load was significantly associated with TTE (p=0.04, HR 1.00004, 95% CI 1.000001 to 1.00007); for every extra ml in total T1 lesion load, the time taken to reach the event was reduced by 0.5%; and (ii) there was a borderline significant association between gender and TTE (p=0.062, HR 1.62, 95% CI 0.96 to 2.73); the time taken for men to reach the event was reduced by 60%.

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The number of T2 lesional voxels extracted from the bilateral CST showed a trend towards a correlation with TTE (p=0.07, HR 1.002, 95% CI 0.99981 to 1.00442); for every extra ml of lesions localised within the CSTs, the time taken to reach the event was reduced by 30%.

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Conversely, there was no correlation between lesion probability on T1-LPMs and TTE, although a statistical trend towards a significant association was found in a region in the right posterior corona radiata which included the CST and the SLF (p<0.08).

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