Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir.

When further sub-divided according to treatment experience, viruses from treatment-naïve patients featured similar variability in all 3 genes, while viruses from treatment-experienced patients featured similar variability in IN and RT and slightly higher variability in PR (Table 2 ), even when only polymorphisms occurring at least twice were considered: 22.7% in PR against 14.3% in IN and 14.8% in RT (Table 2 ), although this difference did not reach statistical significance, probably owing to the small sample size (14 patients).

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