Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor.

The most nominally significant 2-locus haplotype associated with rectal cancer ( P = 0.0028; FDR q = 0.074) was across rs11722146 and rs4648110 (r 2 = 0.10) in which carrying two copies of the minor alleles A-A confers a ~50% increased risk, which is somewhat greater in effect than an OR of 1.2 when rs11722146 A allele was considered independently.

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In logistic regression analyses of composite genotypes, multiplicative P -interaction terms for SNPs across the pathway were significant or borderline significant at the 0.05 level in most models (Additional file 2 ), which supports the hapConstructor finding of a joint effect.

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