Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.

Flk-1 showed a substantial increasing trend, though it did not reach statistical significance, while Tie-2 and c-Kit were both significantly increased in T21 cells ( t -test, P -values=0.02 and 0.009, respectively).

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The increased levels of RUNX1 that we find in T21 FLs appear to be highly significant, and on an average >5 × the euploid liver value, ( Figure 5 ), overall much higher than would be predicted by a mere 1.5 × trisomic increase.

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