Human homolog of Drosophila Hairy and enhancer of split 1, Hes1, negatively regulates δ-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer.

After being treated with 20 μM DAPT for 48 h, Hes1 expression showed a decreasing trend at both the mRNA and protein level in PC3 cells (Figure 7A and 7B ).

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DN-Hes1 led to a moderate reduction in E2F1-induced δ-catenin-luciferase expression in PC3 (Figure 1B ) that did not reach statistical significance.

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