The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma.

There is a general trend indicating enhanced expression of MMP-1 in the presence of either enhanced PEA3 and/or ER81 mRNA alone and this is further increased in samples exhibiting concomitant increased P-ERK levels (Figure 6C ), although due to small sample sizes, these values did not reach statistical significance.

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