It is interesting to note that the recently reported Genetic Association Information Network (GAIN) consortium study of recurrent depression reported nominally significant evidence for association at CACNA1C, 24 although it is important to recognize that the genotyping platform (and hence, single nucleotide polymorphism set) differed from that used in the WTCCC analysis.
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The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia.
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