Prognostic significance of minimal residual disease detected by a simplified flow cytometric assay during remission induction chemotherapy in children with acute lymphoblastic leukemia.

Of note, none of the 8 patients with TEL-AML1 rearrangement at initial diagnosis had MRD of ≥1%, although this failed to reach statistical significance due to small sample size ( P =0.179).

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Multivariate analysis demonstrated that the MRD level on day 14 was an independent prognostic factor with borderline significance.

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