The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.

PLoS One · 2010 · PMC3012690 · PMID 21209938

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0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

Similar to the analysis of SNP rs2066843, homozygous carriers of SNP rs2076756 had less colonic involvement than wildtype patients (p = 0.032) but showed a trend towards ileocolonic disease location (p = 0.058) and had a significant higher rate of penetrating disease phenotype (B3) (p = 0.015; Table 6 ).

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highly significantno p-value reported

We could demonstrate a highly significant association of SNPs rs2066843 and rs2076756 with CD.

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