The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer.

For p68 protein there was also an inverse association between detectable p68 protein (score>0) and expression of Δ133p53β mRNA, although the association with expression of Δ133p53α and Δ133p53γ mRNA did not reach statistical significance ( Table 1B ). p53 isoform protein expression could not be examined by immunohistochemistry due to the lack of isoform-specific antibodies. p68 siRNA knockdown results in induction of Δ133p53 expression in a p53-dependent manner Given that p68 expression is inversely associated with Δ133p53 expression in breast cancers and Δ133p53 is itself a p53 target gene ( Chen et al. , 2009 ), we considered whether p68 could regulate expression of Δ133p53.

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