Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial.

Breast Cancer (Auckl) · 2010 · PMC3018890 · PMID 21234288

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

very close to significanceP = 0.057so close (0.05 < p ≤ 0.1)

In this group, the mean concentration of 16α-OHE was very close to significance ( P = 0.057), and the mean ratio change was not significant.

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a trend towards significanceno p-value reported

For the combined results in both pre- and postmenopausal women, the increase in 2-OHE in the treatment group was highly significant, and there was a trend towards significance in the 2:16a-OHE ratio.

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highly significantno p-value reported

For the treatment group, the mean change in concentration of 2-OHE was highly significant, and there was a trend towards an increase in the mean ratio of 2-OHE to 16α-OHE.

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close-to-significantno p-value reported

The carcinogenic ratio, which combines E3, 4-OHE (1 and 2), 16α-OHE1 and 2-OHE (1 and 2) provided more interesting results, given the significant or close-to-significant results for the treatment groups and lack thereof in the placebo groups.

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