2D ), S14G-HN treated mice showed a trend toward improved recognition, though not reaching statistical significance.
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A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
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The ratio of phosphorylated STAT3 (Tyr705) to total STAT3 showed a weak trend toward increase in STAT3 activity in S14G-HN-treated mice compared with control mice, but no significant difference was detected ( Fig. 9B ).