A groundbreaking prospective observational study through 2004 on the Health Care Cost and Utilization Project (HCUP) Nationwide Inpatient Sample, a 20% sample of hospitalizations nationwide, found a significant reduction in ICD9-coded pneumococcal pneumonia in infants <2 years old and a nonsignificant trend toward such a reduction in both pneumococcal and all-cause pneumonia in persons ≥65 years old ( 11 ).
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Impact of pneumococcal conjugate vaccination of infants on pneumonia and influenza hospitalization and mortality in all age groups in the United States.
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An asterisk next to the year in each panel indicates a significant trend.