While the levels of hASM in the different regions of the brain were not significantly different from each other, rats administered 10 mg/kg hASM showed a trend towards higher levels in areas that were adjacent to the lateral ventricles (e.g., striatum, hippocampus and thalamus).
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Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery.
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