Discussion In this multicentre cohort study of prospectively assessed HIV-1 drug resistance in patients the addition of rPRT to GRT as compared to GRT alone showed a trend towards improved success rates for treatment with increasing levels of antiretroviral pre-treatment.
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Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study.
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For the pre-specified subgroup of patients with >2 previous drug failures this association was highly significant in multivariate analysis when adjusting for age, gender, IDU, baseline HIV-1 RNA, CD4 nadir, number of previous regimens, class of cART, and missed doses of cART (OR 1.68, 95% CI 1.31-2.15) (Table 4 ).