Comparison of IL-1α, Il-1ß and CCL2 transcript expression with the level of immunohistochemical CD45 reactivity (a general marker of microglial reactivity) showed a trend toward a positive correlation with the expression of these elevated transcripts, although this reached significance only in the case of IL-1α (p = 0.038, Figure 8B ).
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Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
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