Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients.

After controlling for possible confounders, including exposure to other antimicrobial agents, the results reported here demonstrate a highly significant association between treatment with levofloxacin or ciprofloxacin and subsequent isolation of MRSA, but not MSSA.

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For each of the two case groups, candidate risk factors that did not reach statistical significance in the multivariable model were only allowed to remain in the model as confounders if their removal changed the coefficient for levofloxacin or ciprofloxacin by > 10%.

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