Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.

None of these nine variants were associated with age-at-onset (Online Resources 7) after Bonferroni correction, however, EBF3 showed nominally significant association with a later age-at-onset of 0.8 years (79.0 years) compared to the major allele (78.2 years; p = 0.03).

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What is clear is that variants of this type are likely to be missed if genetic association studies focus exclusively on replicable associations that become highly significant when many series are combined.

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