Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway.

The delta prolongations were 24.8 ± 11.5 ms and 25.7 ± 15.7 ms for 0.05 nM GLP-1, and 42.2 ± 25.1 ms and 48.5 ± 25.2 ms for 0.5 nM GLP-1 measured at 50% and 90% repolarization, respectively, but these changes did not reach statistical significance at both concentrations ( p > 0.05, n = 6).

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