The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.

Combining genotypes shows a highly significant effect of tau phosphorylation at all three epitopes (Ser396 p = 0.03, Ser202/Thr205 (AT8) p = 0.0002 and Thr231 (AT180) p = 0.008) ( Figure 4C ).

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In our study, APOE KO animals fed a HFD showed a trend for higher levels of soluble Aβ40 and Aβ42 compared to all other APOE genotypes ( Figure 6 ).

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