Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue.

However, no noticeable change in the expression of other adipokines was found, irrespective of their detrimental (TNF α , IL-6, resistin) or beneficial (adiponectin) effect on insulin resistance, with the exception of apelin, the mRNA abundance of which exhibited a 50% reduction that failed to reach statistical significance ( P < .1).

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