Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands.

Inhibitory KIR ligand genes HLA-Bw4 and HLA-C1 are associated with higher CD4+ T cell counts Next, we investigated whether inhibitory KIR ligand genes were associated with the CD4+ T cell count or plasma viral load of the HIV-1 infected subjects. Subjects with Bw4 or C1 showed a trend towards higher CD4+ T cell counts, with no effects on the viral load ( Table 1b ).

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