In contrast, a small reduction in CLEC-2 and Syk tyrosine phosphorylation was observed in response to the CLEC-2 mAb in Fyn-deficient platelets in some but not all experiments, although this did not reach statistical significance ( Fig. 3 D ).
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Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling.
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