Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.

Pharm Res · 2011 · PMC3040319 · PMID 21104302

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

The differences did not reach statistical significance using Fisher exact test ( p = 0.07), though trends were apparent.

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marginally significantp = 0.07so close (0.05 < p ≤ 0.1)

We observed that CDPCP treatment resulted in a lower rate of kidney damage in Oct1+/+ mice than in Oct1-/- mice, and the rate difference was marginally significant ( p = 0.07).

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