Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

PLoS Genet · 2011 · PMC3040659 · PMID 21379329

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp = 3.2×10 −81actually significant

SNPs near APOE gave highly significant results (e.g., rs2075650, p = 3.2×10 −81 ), but no other genome-wide significant evidence for association was obtained in the full sample.

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nominally significantp<0.05actually significant

Two of the three SNPs highlighted initially with strongest evidence for association - rs3818361 in CR1 and rs11136000 in CLU - each reached nominally significant (p<0.05) evidence of association in the unstratified or unadjusted analyses of the CC un and CC all samples.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.