Similar to knockout mice, more plaques were present in the CNS of CD4-depleted mice compare with their CD8-depleted counterparts but these differences did not reach statistical significance compared with the number of plaques in the mock-depleted control mice ( Figure S1 -B).
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IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.
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