Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial.

16 A study in the Gambia comparing oral misoprostol (600 μg) with standard care (2 mg oral ergometrine) administered by trained traditional birth attendants (TBAs) at homebirths, showed a nonsignificant trend in reduction of PPH with misoprostol, and a statistically significant smaller drop in haemoglobin (Hb) in the misoprostol arm. 14 The third trial, testing a 600 μg regimen of sublingual misoprostol administered by midwives in primary healthcare centres in Guinea-Bissau, found that misoprostol was s

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Ten women in the misoprostol group had blood loss ≥1000 ml compared with 19 women in the placebo group; however, this difference between arms did not reach statistical significance.

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