Barely Significant
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Has the lung cancer risk from smoking increased over the last fifty years?

Cancer Causes Control · 2011 · PMC3042098 · PMID 21188493

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a marked trendno p-value reported
mortality rates by calendar year, and it is evident that substantive differences remain across birth cohorts and that there is a marked trend from negative to positive residuals with advancing calendar year after approximately 1980.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.