Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver.

Moreover, we found that BMAL1 binds in accessible and transcriptionally active chromatin regions, as 83% of the sites are located near genes that are expressed (defined as expressed above the median in RNA-Seq liver data [41] ; Figure S3A ; see Materials and Methods ), which represents a highly significant fraction ( p <10 −15 , rank test).

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Other important pathways at the threshold of significance that have been previously linked to circadian function include the insulin [6] , [45] , [51] , [52] and Ppar α [53] – [55] signaling pathways ( Figure S5 ).

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