Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists.

Cancer Chemother Pharmacol · 2011 · PMC3043247 · PMID 20509026

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hedged sentences

0.0001

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.0001actually significant

4 , the overall effect of ondansetron was a reduction of the R+V by about 70% (−0.69, −0.82 to −0.55) and this was highly significant ( Z = 10.05, P < 0.0001).

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did not reach statistical significanceno p-value reported

Ondansetron significantly reduced the R+V in all variants of the model but one; as shown Table 3 , the reduction of R+V did not reach statistical significance when emesis was induced by 10 mg kg −1 cisplatin and quantified for 24 h.

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