Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals.

We declare h g 2 >0 to be nominally significant (P<0.05) if h g 2 is larger than each value analogously estimated from 19 data sets with sample labels randomly permuted (thus, 5% of genes will be nominally significant even in the absence of a true effect).

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While our estimate of ξ trans 2 is not significantly different from zero, ξ cis 2 is highly significant and explains the bulk of our estimate of ρ .

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