Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study.

Although consistent with our observations for weight gain as a continuous trait, the interaction observed in the case-noncase analyses was only borderline significant after correcting for multiple testing ( P = 0.002).

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However, two SNPs showed a nominally significant association with the risk of being a ‘weight gainer’ ( PYY SNP rs1859223, OR = 0.91 per minor allele, P = 0.01; CCK SNP rs11571842, OR = 1.06 per minor allele, P = 0.03) ( Table S3 ).

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