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Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice.

J Neuroinflammation · 2011 · PMC3045937 · PMID 21306618

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Although IGF-I appeared to reduce expression of IL-6, this effect did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.