Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.

At 10 μM, the effect of WM on V 0.5 and VIF (ΔV 0.5 = −98.4 ± 18.6 mV; ΔVIF = 19.7 ± 3.8%; n = 5) was similar to PAO, but the average current potentiation by 10 μM WM (9.6 ± 2.2– and 13.2 ± 2.8–fold increase at +80 and −80 mV, respectively) was less robust and failed to reach statistical significance (+80 mV, P = 0.06; −80 mV, P = 0.27; by Student’s nonpaired t test).

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