Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming.

Anti-tumour effector CTL generated by priming in the presence of reo-infected mel-888 [ 12 ] gave comparable results (Figure 4C ); increases in cell migration were observed for MeWo, SKMEL-28 (p < 0.05) and Mel-888 (although this did not reach statistical significance).

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