Although the lack of IL-21 (IL-21 −/− ) did appear to result in lower Bcl6 protein expression, this did not reach statistical significance (P = 0.073; Figure 6D ).
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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
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0.0730
0.0730