Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.

Malar J · 2011 · PMC3056842 · PMID 21352601

Europe PMC DOI

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0.2400

closest p · 4.8× alpha

0.2400

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did not reach statistical significancep = 0.24not close (p > 0.1)

The median DHA AUC was significantly higher in the non-pregnant control group than in the pregnant group (2787 vs 1731 ng*h/mL, respectively p = 0.0018; estimated ratio of geometric means, 0.68, 90% CI [0.57, 0.81], p = 0.0004); the difference in C max did not reach statistical significance (1285 vs 905 ng*h/mL respectively, p = 0.24; 0.81 [0.63, 1.03], p = 0.15).

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