Levels of the 45 kD and 48 kD PTPN2 splice variants were also decreased with the rs1893217(C) risk allele in PTPN2 , although they did not reach statistical significance after correcting for multiple testing.
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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.
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