Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets.

Nucleic Acids Res · 2011 · PMC3061056 · PMID 21071400

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a clear trendno p-value reported

A clear trend can be established between the identity of the CWWG motif and transactivation from p53 half-sites ( 20 ).

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highly significantno p-value reported

However, the difference in k 12 values among these sites, and between them and that of the Con1 target, is so large that it allows us to conclude that the changes in binding cooperativity between the sites are highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.