Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.

PLoS One · 2011 · PMC3061857 · PMID 21445287

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

of borderline significanceP = 0.055so close (0.05 < p ≤ 0.1)

A significant effect of time on SEPS1 mRNA level was identified using ANOVA. Post-hoc testing found that SEPS1 mRNA increased (P = 0.007) one week after the influenza vaccine (week 11) compared to pre-vaccination (week 10) in the 100 μg/day Se-yeast group and there was a similar increase in the 200 μg/day Se-yeast group, which was of borderline significance (P = 0.055).

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a negative trendno p-value reported

The reduction at week 10 in SEPW1 mRNA levels was negatively correlated with plasma Se concentration (P = 0.022); a negative trend was also observed at the majority of the sampling points of the intervention period ( Figure 2 ).

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