Barely Significant
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Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis.

Am J Trop Med Hyg · 2011 · PMC3062442 · PMID 21460003

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quite significantno p-value reported
63 The effect of various doxycycline salts and formulations such as oral suspensions, tablets, capsules, and enteric-coated tablets are likely quite significant in their ability to cause GI adverse events.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.