"Fluctuograms" reveal the intermittent intra-protein communication in subtilisin Carlsberg and correlate mechanical coupling with co-evolution.

PLoS Comput Biol · 2011 · PMC3063751 · PMID 21455286

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quite significantno p-value reported

Among the 9 reported mutation sites, even though residue 160 is not covered, its calculated mechanical coupling variation is actually quite significant; the average of 's is 15.4 kcal/mol/Å 2 .

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