The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin.

Diabetes · 2011 · PMC3064091 · PMID 21386086

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did not reach statistical significanceno p-value reported

It is important to note that even though pAMPK levels were increased, pACC did not reach statistical significance, probably because of the different kinetics of phosphorylation of both enzymes ( 6 ).

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