Carotid intima-media thickness as a surrogate marker of cardiovascular disease in diabetes.

The authors found that pioglitazone induced regression of mean CIMT from 0.839 ± 0.1873 to 0.780 ± 0.1571 mm; P =0.002), although the between-group difference did not reach statistical significance. 115 The Pioglitazone in the Prevention of Diabetes (PIPOD) study assessed the effects of pioglitazone in Hispanic women with prior gestational diabetes mellitus who had previously completed the troglitazone in the Prevention of Diabetes (TRIPOD) study. 116 – 118 Thirty-one women came to PIPOD from the troglitazone arm while 30 came from the placebo arm of TRIPOD.

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