β2-Adrenergic ion-channel coupled receptors as conformational motion detectors.

6 , for construct β 2 -K -62-25 , mutation E122 W appeared to reduce the amplitude of the agonist-induced signal (from 63.5% to 51% at maximum activation) and to increase dissociation constant (from 149 nM to 247 nM) but these effects did not reach statistical significance (p = 0.12 for amplitudes; p = 0.24 for affinities).

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